[Genetic dependency of blood pressure and heart rate in patients with arterial hypertension and obesity].

BACKGROUND The aim of the study was to determine the effect of gene polymorphisms Arg389Gly ADRβ1 gene and T393C gene GNAS1 on the level of heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) in hypertensive patients according to body mass index (BMI). PATIENTS AND METHODS The study involved 166 patients with hypertension and 90 healthy individuals. Patients of the main group was divided according to BMI into three subgroups: I subgroup--with normal body weight, II subgroup--overweight, II subgroup--obesity. Gene polymorphism is determined using polymerase chain reaction and subsequent analysis of restriction fragments. RESULTS Patients from subgroups II and III, who had presence of genotypes Arg389Arg, Arg389Gly, had higher HR, SBP than in patients with genotype Gly389Gly (p = 0.010 and p = 0.001; p = 0.010 and p = 0.001, respectively). In the analysis of DBP, the dependence of its level of polymorphism Arg389Gly of ADRβ1 gene was found only in I subgroup (p < 0.001). During the analysis of polymorphism T393C of GNAS1 gene only in patients from III subgroup was found a higher heart rate in patients with T393T genotype relatively to C393C genotype, but this difference was not statistically significant (p = 0.191). CONCLUSION There is a direct correlation between HR and SBP in hypertensive patients with overweight and obesity from polymorphism Arg389Gly of ADRβ1 gene, in hypertensive patients with normal body weight from this polymorphism depends DBP. Clinical manifestations of hypertension do not depend on polymorphism T393C of GNAS1 gene.